Conveniently located in the heart of the nation, Cape Girardeau is the largest community in southeast Missouri. The city is located 115 miles south of St. Louis, Missouri and 171 miles north of Memphis, Tennessee and approximately 110 miles from the population center of the US. Interstate 55 runs through Cape Girardeau making it an easy, trouble-free drive from almost anywhere in the midwest.
Reputable meeting facilities, lively entertainment attractions, specialty shops, outstanding sports facilities, more than 1,000 lodging accommodations and more than 120 delicious restaurants combine to make Cape Girardeau a multi-state, regional hub and premiere location in southeast Missouri.

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Midwest Mileage Chart from Major Midwestern Cities (152k)
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